In 1863, Emperor Napoleon III held a Salon of the Refused for those artists rejected for the annual art exhibition of the Academy of Fine Arts.
The meaningful work you believe you must do will not necessarily be recognised by the establishments and powers that be.
You need to get used to this and move on in order to continue developing the unique contribution just where it matters most, in the eyes and lives of those you produce your art for.
One day the establishment may recognise what you’re doing, but let’s be honest, that’s not the reason you’ve taken this path. And, just like Napoleon, you too can create salons of the refused.*
(*Following writing this, I found myself listed amongst the members of just such a salon; we are living in interesting times.)